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Research Introduction

Masaru Tanaka

Design of Novel 2D/3D Biocompatible Polymers
  Based on Self-organized Water Structure
  for Medical Devices and Tissue Engineering

Masaru Tanaka The design of biocompatible 2D surfaces and 3D nano/micro topographies based on self-organization inspired by biology has a variety of potential applications in medical devices and tissue engineering. Many polymers have been studied to obtain biocompatible surfaces, and several mechanisms have been proposed for the biocompatibility of polymers [1]. It has been pointed out that biocompatibility depends on the various physicochemical properties of the material surface. We have reported that

1) biocompatible 2D surface using poly(2-methoxyethyl acrylate) (PMEA) [2-11] and
2) honeycomb-patterned 3D films with regular interconnected pores that is formed by self-organization [13-15].

1) We found that hydrated PMEA has unique water observed as a cold crystallization (CC) of water in differential scanning calorimetry (DSC), ATR-IR, NMR, and AFM. This CC is interpreted as the ice formation at low temperature, that belongs to the intermediate water in PMEA. The CC peak was observed for hydrated PEG, poly (2-methacryloyloxyethyl phosphorylcholine)(PMPC), PVP, as well as various proteins, polysaccharides and DNA (RNA), which are well-known as biocompatible polymers. The amount of the intermediate water of PMEA-analogous polymers affected the stem cell and cancer cell adhesion. The control of stem cell cancer cell adhesion by biocompatible polymers will open the way for a new cell therapy called as personalized medicine.
2) We also found that the topography of the 3D films in contact with cancer cells has a potential anticancer effect. In these results, the 3D films could regulate cell adhesion, morphologies and functions in the absence of growth factors and anti-cancer drugs. A bile-duct stent which is covered by the 3D films is now commercially available in the world clinical market. We will highlight that

1) the reasons for the selective adhesion of stem and cancer cells on PMEA by comparing the structure of water in hydrated PMEA to the water structure of other polymers and
2) the reasons that 3D films exerted a strong influence on normal, cancer and stem cells morphology, proliferation, differentiation, cytoskeleton, focal adhesion, and functions including matrix production profiles.

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  1. T. Tsuruta, J. Biomat. Sci. Polym. Ed, 21, 1831 (2010).
  2. M. Tanaka, T. Motomura, M. Kawada, T. Anzai, K. Shimura, M. Onishi, Biomaterials, 21, 1471 (2000).
  3. M. Tanaka, A. Mochizuki, N. Ishii, T. Motomura, T. Hatakeyama, Biomacromolecules, 3, 36 (2002).
  4. M. Tanaka, A. Mochizuki, J. Biomed. Mater. Res., 68A, 684 (2004).
  5. T. Hatakeyama, M. Tanaka, A. Kishi, H. Hatakeyama, Thermochim. Acta, 532, 159 (2012).
  6. I. Javakhishvili, M. Tanaka, K. Jankova, S. Hvilsted , Macromol. Rapid Commun., 33, 319 (2012).
  7. S. Morita, M. Tanaka, Y. Ozaki , Langmuir, 23, 3750 (2007).
  8. Y. Miwa,H. Ishida, H. Saitô, M. Tanaka, A. Mochizuki , Polymer, 50, 6091 (2009).
  9. M. Tanaka, A. Mochizuki, J. Biomat. Sci. Polym. Ed, 21, 1849 (2010).
  10. T. Hayashi, Y. Tanaka, Y. Koide, M. Tanaka, M. Hara, Phys. Chem. Chem. Phys, 14, 10194 (2012).
  11. M. Tanaka, T. Hayashi, S. Morita, Polym. J, 45,711 (2013).
  12. T. Hoshiba, M. Nikaido, M. Tanaka, Adv. Healthcare Mater., in press.
  13. M. Tanaka, Biochimica et Biophysica Acta, 1810, 251 (2011).
  14. M. Birch, M. Tanaka, G. Kirmizidis et al, Tissue Engineering, Part A. 19(17,18), 1 (2013).
  15. H. Choi, M. Tanaka, K. Sugimoto et al, Nanomedicine, in press.